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Jigsaw Magnesium w/SRT Involved in more than 325 biochemical reactions, some of the early symptoms of magnesium deficiency include body aches, chronic constipation, headaches and migraines, insulin resistance, PMS, leg cramps, muscle twitches, and more. Left untreated, a magnesium deficiency can lead to more life-threatening conditions such as heart disease, hypertension, stroke, type 2 diabetes, osteoporosis, and others. Tags: muscle energy sleep migraines headaches bone structure PMS blood sugar glucose levels pressure stress